AGREEMENT ON THE DETAILS OF THE ARRANGEMENT OF
                       ENCUMBRANCES IN THE SITE AGREEMENT

On 15 February 2000, the University of Iceland (UI), Islensk erfoagreining ehf.
(IE) and the City of Reykjavik entered into an Agreement on the allocation of a
building site to IE. The aim of the Agreement is to promote co-operation and
encourage the development of vigorous scientific and industrial activities in
the field of health science and biotechnological research in the University
campus area.

The Agreement contains provisions, inter alia, on the purchase rights and right
of first refusal at assessment value for UI, to be further defined in a Site
Agreement.

IE and UI have now agreed on the following arrangements of the above
encumbrances in the final Site Agreement for the property.

1.    UI has the right of first refusal to the property. UI shall be offered the
      right of first refusal in writing and in a verifiable manner at a price
      that shall be the lower of the two following options: (a) the offered
      selling price or (b) the depreciated replacement value of installations on
      the site pursuant to public records plus the restated purchasing price of
      the site rights. The selling price and other terms shall be specified in
      detail in the offer submitted for first refusal and the offer shall be
      accompanied by a copy of the purchase offer that UI is invited to take
      over. In the event of an exchange of properties, the purchase offer shall
      specify the estimated cash value of the offered rights and that amount
      shall be used in the determination of the price presented to the holder of
      the right of first refusal. In the event that the price offered to the
      holder of the right of first refusal is the depreciated replacement value
      of installations on the site and the public valuation of the site, UI
      shall pay the purchasing price in cash within 15 days from the date that
      the University accepted the offer to exercise its right of first refusal.
      UI shall reply in writing to the offer to exercise its option within 30
      days from the date of receipt by the University of the offer. In the event
      that UI neglects to answer within that time the University shall forfeit
      its right to purchase.

2.    In the event that IE ceases its activities on the site, UI shall be
      invited to purchase the property at the depreciated replacement value of
      installations on the site and the adjusted purchasing price of the site
      rights pursuant to item 2 above. The activities of IE are not regarded as
      having ceased if:

            a)    IE is merged with another company, whether the merger is
                  effected through the take-over by IE of another company, the
                  take-over of IE by another company or the establishment of a
                  new company where the merged company continues activities on
                  the site.

            b)    IE is divided into more than one company and one of these
                  continues activities on the site, provided that the activities
                  on the site constitute high-tech industry, research and
                  university-level teaching.

In witness of the above, the parties attach their signatures to this annex in
the presence of witnesses.

                                     Reykjavik, 21 December 2001

For the University of Iceland        For Islensk erfoagreining ehf.
Pall Skulason [sign.]
                                     Tanja Zharov [sign.]
Witnesses                            [Illegible signature]
Tomas Sigurosson [sign.]             Kari Stefansson, [sign.]
180966-3159

Source: OneCLE Business Contracts.